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Codominant segregation of the NcoI RFLP was observed in 3 two-generation families.

Construct size (kb): 4.0

DNA: cDNA

Insert lengths(kb): 1.233999967575073

Tissue: placenta

Gene product: colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog( CD115 antigen, FMS proto-oncogene, macrophage colony stimulating factor I receptor, colony stimulating factor 1 receptor) [FMS]

Alleles: A1, B1, B2, A1, B1, B2, A2, A2

Restriction digests of the clone give the following sizes (kb): EcoRI--2.7, 1.3; BamHI--4.1; HindIII--3.7, 0.45; PstI--3.3, 0.68, + 2 smaller; SalI--2.7, 1.3.

Codominant segregation of the NcoI RFLP was observed in 3 two-generation families.

The insert contains approximately 100 bp 5' untranslated sequence and encodes about the first 380 amino acids--including the putative signal sequence and several potential glycosylation sites.

Enzyme(s) not detecting polymorphism: HindIII, BamHI, EcoRV, SstI, PstI, PvuII, MspI, XbaI, XmaI, HinfI, BglII, ApaI, AluI.